Version 5.4
Homo sapiens Protein: NDNL2
Summary
InnateDB Protein IDBP-4672.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NDNL2
Protein Name necdin-like 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000330694
InnateDB Gene IDBG-4670 (NDNL2)
Protein Structure
UniProt Annotation
Function Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest. {ECO:0000269PubMed:20864041}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269PubMed:18086888}. Chromosome, telomere {ECO:0000305PubMed:18086888}.
Disease Associations
Tissue Specificity Ubiquitous. {ECO:0000269PubMed:11782285}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0031398 positive regulation of protein ubiquitination
GO:0040008 regulation of growth
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0030915 Smc5-Smc6 complex
Protein Structure and Domains
PDB ID
InterPro IPR002190 MAGE protein
PFAM PF01454
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96MG7
PhosphoSite PhosphoSite-Q96MG7
TrEMBL
UniProt Splice Variant
Entrez Gene 56160
UniGene Hs.732214
RefSeq NP_619649
HUGO HGNC:7677
OMIM 608243
CCDS CCDS10023
HPRD 10503
IMGT
EMBL AF320911 AF490510 AK056957 AK074138 BC041166 BC053999
GenPept AAG38607 AAH41166 AAH53999 AAM08357 BAB71325 BAB84964

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca