InnateDB Protein
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IDBP-46730.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TIMM10
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Protein Name
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translocase of inner mitochondrial membrane 10 homolog (yeast)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000257245
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InnateDB Gene
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IDBG-46728 (TIMM10)
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Protein Structure
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Function |
Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. {ECO:0000269PubMed:14726512}.
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Subcellular Localization |
Mitochondrion inner membrane {ECO:0000269PubMed:11489896, ECO:0000269PubMed:14726512}; Peripheral membrane protein {ECO:0000269PubMed:11489896, ECO:0000269PubMed:14726512}; Intermembrane side {ECO:0000269PubMed:11489896, ECO:0000269PubMed:14726512}.
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Disease Associations |
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Tissue Specificity |
Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle. {ECO:0000269PubMed:10552927, ECO:0000269PubMed:10611480}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
16
[view]
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Protein-Protein |
15
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
GO:0005739
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mitochondrion
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GO:0005743
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mitochondrial inner membrane
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GO:0005744
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mitochondrial inner membrane presequence translocase complex
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GO:0005758
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mitochondrial intermembrane space
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GO:0042719
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mitochondrial intermembrane space protein transporter complex
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PDB ID |
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InterPro |
IPR004217
Tim10/DDP family zinc finger
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PFAM |
PF02953
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P62072
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PhosphoSite |
PhosphoSite-P62072
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
26519
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UniGene |
Hs.603158
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RefSeq |
NP_036588
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HUGO |
HGNC:11814
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OMIM |
602251
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CCDS |
CCDS7959
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HPRD |
03768
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IMGT |
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EMBL |
AF150089
AF152354
AK289751
BC032133
CH471076
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GenPept |
AAD39995
AAF15104
AAH32133
BAF82440
EAW73753
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