Version 5.4
Homo sapiens Protein: FILIP1L
Summary
InnateDB Protein IDBP-47186.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FILIP1L
Protein Name filamin A interacting protein 1-like
Synonyms DOC-1; DOC1; GIP130; GIP90;
Species Homo sapiens
Ensembl Protein ENSP00000346560
InnateDB Gene IDBG-47184 (FILIP1L)
Protein Structure
UniProt Annotation
Function Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor- associated vasculature. {ECO:0000269PubMed:18794120}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:18794120}. Membrane {ECO:0000269PubMed:18794120}. Nucleus {ECO:0000269PubMed:18794120}.
Disease Associations
Tissue Specificity Expressed in endothelial cells, colon and colon cancers. In the colon, expressed in the vasculature and muscularis mucosa. In colon cancer, strongly expressed in tumor stroma and the vasculature (at protein level). Expressed in ovarian epithelial cells. Down-regulated in ovarian cancer. {ECO:0000269PubMed:18794120, ECO:0000269PubMed:8314147}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR000533 Tropomyosin
IPR009053 Prefoldin
IPR019131 Cortactin-binding protein-2, N-terminal
PFAM PF00261
PF12718
PF09727
PRINTS PR00194
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q4L180
PhosphoSite PhosphoSite-Q4L180
TrEMBL C9JYJ6
UniProt Splice Variant
Entrez Gene 11259
UniGene Hs.727360
RefSeq NP_878913
HUGO HGNC:24589
OMIM 612993
CCDS CCDS43117
HPRD 16832
IMGT
EMBL AC024938 AC069222 AC117419 AC129803 AC130887 AF329092 AF514867 AF514868 AF514869 AY642382 BC020941 BC027860 CH471052 EU531865 EU531866 U53445
GenPept AAA98972 AAH20941 AAH27860 AAN16206 AAQ08177 AAQ08178 AAQ08179 AAV34207 ACB37436 ACB37437 EAW79833

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca