InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TOMM70A

Summary

InnateDB Protein

IDBP-47325.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TOMM70A

Protein Name

translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000284320

InnateDB Gene

IDBG-47323 (TOMM70A)

Protein Structure

UniProt Annotation

Function

Receptor that accelerates the import of all mitochondrial precursor proteins. {ECO:0000250}.

Subcellular Localization

Mitochondrion outer membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	37 [view]
Protein-Protein	35 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008320	protein transmembrane transporter activity

Biological Process

GO:0006626	protein targeting to mitochondrion
GO:0044267	cellular protein metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0071806	protein transmembrane transport

Cellular Component

GO:0005739	mitochondrion
GO:0005742	mitochondrial outer membrane translocase complex
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001440 Tetratricopeptide TPR1
IPR013026 Tetratricopeptide repeat-containing domain
IPR013105 Tetratricopeptide TPR2
IPR019734 Tetratricopeptide repeat

PFAM

PF00515
PF07719
PF13174
PF13176
PF13181

PRINTS

PIRSF

SMART

SM00028

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O94826