InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ABL2

Summary

InnateDB Protein

IDBP-473370.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ABL2

Protein Name

v-abl Abelson murine leukemia viral oncogene homolog 2

Synonyms

ABLL; ARG;

Species

Homo sapiens

Ensembl Protein

ENSP00000426831

InnateDB Gene

IDBG-105099 (ABL2)

Protein Structure

UniProt Annotation

Function

Non-receptor tyrosine-protein kinase that plays an ABL1- overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin- bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. {ECO:0000269PubMed:15735735, ECO:0000269PubMed:15886098, ECO:0000269PubMed:16678104, ECO:0000269PubMed:17306540, ECO:0000269PubMed:18945674}.

Subcellular Localization

Cytoplasm, cytoskeleton.

Disease Associations

Tissue Specificity

Widely expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	51 [view]
Protein-Protein	48 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003785	actin monomer binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0030145	manganese ion binding
GO:0051015	actin filament binding

Biological Process

GO:0006464	cellular protein modification process
GO:0006468	protein phosphorylation
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007411	axon guidance
GO:0010506	regulation of autophagy
GO:0010976	positive regulation of neuron projection development
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030100	regulation of endocytosis
GO:0030155	regulation of cell adhesion
GO:0051353	positive regulation of oxidoreductase activity
GO:0071300	cellular response to retinoic acid
GO:2000145	regulation of cell motility
GO:2000249	regulation of actin cytoskeleton reorganization

Cellular Component

GO:0005829	cytosol
GO:0015629	actin cytoskeleton

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR000980 SH2 domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001452 SH3 domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR003646 SH3-like domain, bacterial-type
IPR011009 Protein kinase-like domain
IPR011511 Variant SH3 domain
IPR015015 F-actin binding
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM