InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RGL2

Summary

InnateDB Protein

IDBP-473378.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RGL2

Protein Name

ral guanine nucleotide dissociation stimulator-like 2

Synonyms

HKE1.5; KE1.5; RAB2L;

Species

Homo sapiens

Ensembl Protein

ENSP00000420211

InnateDB Gene

IDBG-304189 (RGL2)

Protein Structure

UniProt Annotation

Function

Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.

Experimentally validated
Total	19 [view]
Protein-Protein	17 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005088	Ras guanyl-nucleotide exchange factor activity

Biological Process

GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007265	Ras protein signal transduction
GO:0032320	positive regulation of Ras GTPase activity
GO:0043547	positive regulation of GTPase activity
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005575	cellular_component
GO:0005622	intracellular

Protein Structure and Domains

PDB ID

InterPro

IPR000159 Ras-association
IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
IPR023578 Ras guanine nucleotide exchange factor domain
IPR029071 Ubiquitin-related domain

PFAM

PF00788
PF00618
PF00617

PRINTS

PIRSF

SMART

SM00314
SM00229
SM00147

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O15211