InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDC6

Summary

InnateDB Protein

IDBP-47361.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDC6

Protein Name

cell division cycle 6 homolog (S. cerevisiae)

Synonyms

CDC18L; HsCDC18; HsCDC6;

Species

Homo sapiens

Ensembl Protein

ENSP00000209728

InnateDB Gene

IDBG-47359 (CDC6)

Protein Structure

UniProt Annotation

Function

Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.

Subcellular Localization

Nucleus {ECO:0000269PubMed:9566895}. Cytoplasm {ECO:0000269PubMed:9566895}. Note=The protein is nuclear in G1 and cytoplasmic in S-phase cells.

Disease Associations

Meier-Gorlin syndrome 5 (MGORS5) [MIM:613805]: A syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal. {ECO:0000269PubMed:21358632}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	75 [view]
Protein-Protein	63 [view]
Protein-DNA	12 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0017111	nucleoside-triphosphatase activity
GO:0019900	kinase binding

Biological Process

GO:0000076	DNA replication checkpoint
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082	G1/S transition of mitotic cell cycle
GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006260	DNA replication
GO:0007067	mitotic nuclear division
GO:0007089	traversing start control point of mitotic cell cycle
GO:0008156	negative regulation of DNA replication
GO:0008285	negative regulation of cell proliferation
GO:0030071	regulation of mitotic metaphase/anaphase transition
GO:0032467	positive regulation of cytokinesis
GO:0051984	positive regulation of chromosome segregation

Cellular Component

GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005819	spindle
GO:0005829	cytosol
GO:0051233	spindle midzone

Protein Structure and Domains

PDB ID

InterPro

IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR015163 CDC6, C-terminal domain
IPR016314 Cell division protein Cdc6/18
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00004
PF07724
PF13304
PF09079

PRINTS

PIRSF

PIRSF001767

SMART

SM00382
SM01074

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt