InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GUCY1A3

Summary

InnateDB Protein

IDBP-473667.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GUCY1A3

Protein Name

guanylate cyclase 1, soluble, alpha 3

Synonyms

GC-SA3; GUC1A3; GUCA3; GUCSA3; GUCY1A1; MYMY6;

Species

Homo sapiens

Ensembl Protein

ENSP00000421493

InnateDB Gene

IDBG-42375 (GUCY1A3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004383	guanylate cyclase activity
GO:0004872	receptor activity
GO:0005525	GTP binding
GO:0016849	phosphorus-oxygen lyase activity
GO:0020037	heme binding

Biological Process

GO:0006182	cGMP biosynthetic process
GO:0007263	nitric oxide mediated signal transduction
GO:0007596	blood coagulation
GO:0008015	blood circulation
GO:0009190	cyclic nucleotide biosynthetic process
GO:0035556	intracellular signal transduction

Cellular Component

GO:0008074	guanylate cyclase complex, soluble
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
IPR011644 Heme-NO binding
IPR011645 Haem NO binding associated
IPR024096 NO signalling/Golgi transport ligand-binding domain
IPR029787 Nucleotide cyclase

PFAM

PF00211
PF07700
PF07701

PRINTS

PIRSF

SMART

SM00044

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q02108