Version 5.4
Homo sapiens Protein: CATSPER4
Summary
InnateDB Protein IDBP-473788.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CATSPER4
Protein Name cation channel, sperm associated 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000429464
InnateDB Gene IDBG-94509 (CATSPER4)
Protein Structure
UniProt Annotation
Function Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH. {ECO:0000269PubMed:21412338, ECO:0000269PubMed:21412339}.
Subcellular Localization Cell projection, cilium, flagellum membrane; Multi-pass membrane protein. Note=Specifically located in the principal piece of sperm tail.
Disease Associations
Tissue Specificity Testis-specific. {ECO:0000269PubMed:12932298, ECO:0000269PubMed:17347248}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005245 voltage-gated calcium channel activity
Biological Process
GO:0006811 ion transport
GO:0007275 multicellular organismal development
GO:0007283 spermatogenesis
GO:0007338 single fertilization
GO:0030154 cell differentiation
GO:0030317 sperm motility
GO:0032504 multicellular organism reproduction
GO:0034765 regulation of ion transmembrane transport
GO:0035036 sperm-egg recognition
GO:0055085 transmembrane transport
GO:0070509 calcium ion import
GO:0086010 membrane depolarization during action potential
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0036128 CatSper complex
Protein Structure and Domains
PDB ID
InterPro IPR005821 Ion transport domain
PFAM PF00520
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7RTX7
PhosphoSite PhosphoSite-Q7RTX7
TrEMBL
UniProt Splice Variant
Entrez Gene 378807
UniGene Hs.733788
RefSeq
HUGO HGNC:23220
OMIM 609121
CCDS
HPRD 18607
IMGT
EMBL AL355877 BC128138 BC128139 BN000273
GenPept AAI28139 AAI28140 CAE30475 CAH71538

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca