InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ALAS1

Summary

InnateDB Protein

IDBP-473917.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALAS1

Protein Name

aminolevulinate, delta-, synthase 1

Synonyms

ALAS; ALAS3; ALASH; MIG4;

Species

Homo sapiens

Ensembl Protein

ENSP00000418779

InnateDB Gene

IDBG-38254 (ALAS1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Mitochondrion matrix.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	49 [view]
Protein-Protein	49 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003870	5-aminolevulinate synthase activity
GO:0030170	pyridoxal phosphate binding

Biological Process

GO:0006778	porphyrin-containing compound metabolic process
GO:0006782	protoporphyrinogen IX biosynthetic process
GO:0006783	heme biosynthetic process
GO:0008152	metabolic process
GO:0009058	biosynthetic process
GO:0033014	tetrapyrrole biosynthetic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000192 Aminotransferase class V domain
IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme
IPR004839 Aminotransferase, class I/classII
IPR010961 Tetrapyrrole biosynthesis, 5-aminolevulinic acid synthase
IPR015118 5-aminolevulinate synthase presequence
IPR015424 Pyridoxal phosphate-dependent transferase

PFAM

PF00266
PF01053
PF00155
PF09029

PRINTS

PIRSF

PIRSF001434

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P13196