InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: U2AF1

Summary

InnateDB Protein

IDBP-474128.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

U2AF1

Protein Name

U2 small nuclear RNA auxiliary factor 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000418705

InnateDB Gene

IDBG-4654 (U2AF1)

Protein Structure

UniProt Annotation

Function

Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron. {ECO:0000269PubMed:8647433}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:15096518}. Nucleus speckle {ECO:0000269PubMed:15096518}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 139 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	139 [view]
Protein-Protein	138 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006366	transcription from RNA polymerase II promoter
GO:0006369	termination of RNA polymerase II transcription
GO:0006397	mRNA processing
GO:0006406	mRNA export from nucleus
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0031124	mRNA 3'-end processing

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005681	spliceosomal complex
GO:0015030	Cajal body
GO:0016607	nuclear speck
GO:0071013	catalytic step 2 spliceosome

Protein Structure and Domains

PDB ID

InterPro

IPR000504 RNA recognition motif domain
IPR000571 Zinc finger, CCCH-type
IPR003954 RNA recognition motif domain, eukaryote
IPR009145 U2 auxiliary factor small subunit

PFAM

PF00076
PF00642

PRINTS

PR01848

PIRSF

SMART

SM00360
SM00356
SM00361

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt