InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LRPAP1

Summary

InnateDB Protein

IDBP-474150.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LRPAP1

Protein Name

low density lipoprotein receptor-related protein associated protein 1

Synonyms

A2MRAP; A2RAP; alpha-2-MRAP; HBP44; MRAP; MYP23; RAP;

Species

Homo sapiens

Ensembl Protein

ENSP00000421922

InnateDB Gene

IDBG-8233 (LRPAP1)

Protein Structure

UniProt Annotation

Function

Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330.

Subcellular Localization

Endoplasmic reticulum. Cytoplasm. Cell surface. Note=Intracellular and associated with cell surface receptors. Found in the endoplasmic reticulum.

Disease Associations

Myopia 23, autosomal recessive (MYP23) [MIM:615431]: A refractive error of the eye, in which parallel rays from a distant object come to focus in front of the retina, vision being better for near objects than for far. {ECO:0000269PubMed:23830514}. Note=The disease is caused by mutations affecting the gene represented in this entry.Note=In complex with the alpha-2-MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.

Experimentally validated
Total	27 [view]
Protein-Protein	26 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004873	asialoglycoprotein receptor activity
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0035473	lipase binding
GO:0048019	receptor antagonist activity
GO:0050750	low-density lipoprotein particle receptor binding
GO:0051082	unfolded protein binding
GO:0070326	very-low-density lipoprotein particle receptor binding

Biological Process

GO:0006457	protein folding
GO:0006898	receptor-mediated endocytosis
GO:0010916	negative regulation of very-low-density lipoprotein particle clearance
GO:0016192	vesicle-mediated transport
GO:0032091	negative regulation of protein binding
GO:1900116	extracellular negative regulation of signal transduction
GO:1900222	negative regulation of beta-amyloid clearance

Cellular Component

GO:0005576	extracellular region
GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0031982	vesicle
GO:0048237	rough endoplasmic reticulum lumen