InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ASPH

Summary

InnateDB Protein

IDBP-474189.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ASPH

Protein Name

aspartate beta-hydroxylase

Synonyms

AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN; junctin;

Species

Homo sapiens

Ensembl Protein

ENSP00000429286

InnateDB Gene

IDBG-23064 (ASPH)

Protein Structure

UniProt Annotation

Function

Isoform 1: specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins. {ECO:0000269PubMed:22586105}.Isoform 8: membrane-bound Ca(2+)-sensing protein, which is a structural component of the ER-plasma membrane junctions. Isoform 8 regulates the activity of Ca(+2) released-activated Ca(+2) (CRAC) channels in T-cells. {ECO:0000269PubMed:22586105}.

Subcellular Localization

Isoform 1: Endoplasmic reticulum membrane; Single-pass type II membrane protein.Isoform 8: Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Disease Associations

Tissue Specificity

Isoform 1 is detected in all tissues tested. Isoform 8 is mainly expressed in pancreas, heart, brain, kidney and liver. Isoform 8 is expressed in kidney (at protein level). {ECO:0000269PubMed:11007777}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004597	peptide-aspartate beta-dioxygenase activity
GO:0005198	structural molecule activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008307	structural constituent of muscle
GO:0009055	electron carrier activity
GO:0044325	ion channel binding

Biological Process

GO:0005513	detection of calcium ion
GO:0006936	muscle contraction
GO:0010524	positive regulation of calcium ion transport into cytosol
GO:0010649	regulation of cell communication by electrical coupling
GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0031585	regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0032237	activation of store-operated calcium channel activity
GO:0033198	response to ATP
GO:0045862	positive regulation of proteolysis
GO:0045893	positive regulation of transcription, DNA-templated
GO:0055114	oxidation-reduction process
GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity
GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity
GO:0070588	calcium ion transmembrane transport
GO:0071277	cellular response to calcium ion
GO:0090316	positive regulation of intracellular protein transport
GO:0097202	activation of cysteine-type endopeptidase activity

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0014701	junctional sarcoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030176	integral component of endoplasmic reticulum membrane
GO:0032541	cortical endoplasmic reticulum
GO:0033017	sarcoplasmic reticulum membrane
GO:0033018	sarcoplasmic reticulum lumen
GO:0034704	calcium channel complex