InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MECOM

Summary

InnateDB Protein

IDBP-474194.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MECOM

Protein Name

MDS1 and EVI1 complex locus

Synonyms

AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3;

Species

Homo sapiens

Ensembl Protein

ENSP00000420048

InnateDB Gene

IDBG-64075 (MECOM)

Protein Structure

UniProt Annotation

Function

Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. {ECO:0000269PubMed:10856240, ECO:0000269PubMed:11568182, ECO:0000269PubMed:15897867, ECO:0000269PubMed:16462766, ECO:0000269PubMed:19767769, ECO:0000269PubMed:9665135}.

Subcellular Localization

Nucleus. Nucleus speckle.

Disease Associations

Note=A chromosomal aberration involving EVI1 is a cause of chronic myelogenous leukemia (CML). Translocation t(3;21)(q26;q22) with RUNX1/AML1.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 65 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	65 [view]
Protein-Protein	63 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006915	apoptotic process
GO:0030154	cell differentiation
GO:0043069	negative regulation of programmed cell death
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046329	negative regulation of JNK cascade
GO:0051726	regulation of cell cycle
GO:0071425	hematopoietic stem cell proliferation