Version 5.4
Homo sapiens Protein: GINS4
Summary
InnateDB Protein IDBP-474234.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GINS4
Protein Name GINS complex subunit 4 (Sld5 homolog)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000428754
InnateDB Gene IDBG-18945 (GINS4)
Protein Structure
UniProt Annotation
Function The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS4 is important for GINS complex assembly. GINS complex seems to bind preferentially to single-stranded DNA. {ECO:0000269PubMed:17417653}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 30 [view]
Protein-Protein 30 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0006260 DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR008591 GINS complex, subunit Sld5
IPR021151 GINS complex
PFAM PF05916
PRINTS
PIRSF PIRSF007764
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BRT9
PhosphoSite PhosphoSite-Q9BRT9
TrEMBL E5RFF9
UniProt Splice Variant
Entrez Gene 84296
UniGene Hs.706190
RefSeq XP_005273716
HUGO HGNC:28226
OMIM 610611
CCDS CCDS6116
HPRD 11583
IMGT
EMBL AC009630 AK095334 AK313373 BC005995 BC027454 CH471080
GenPept AAH05995 AAH27454 BAG36172 BAG53029 EAW63256 EAW63257

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca