InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TERT

Summary

InnateDB Protein

IDBP-474262.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TERT

Protein Name

telomerase reverse transcriptase

Synonyms

CMM9; DKCA2; DKCB4; EST2; hEST2; hTRT; PFBMFT1; TCS1; TP2; TRT;

Species

Homo sapiens

Ensembl Protein

ENSP00000425003

InnateDB Gene

IDBG-10998 (TERT)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 97 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	97 [view]
Protein-Protein	96 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003720	telomerase activity
GO:0003721	telomeric template RNA reverse transcriptase activity
GO:0003964	RNA-directed DNA polymerase activity
GO:0005515	protein binding
GO:0042162	telomeric DNA binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0070034	telomeric RNA binding

Biological Process

GO:0000723	telomere maintenance
GO:0007004	telomere maintenance via telomerase
GO:0022616	DNA strand elongation
GO:0032203	telomere formation via telomerase
GO:0090399	replicative senescence
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0000781	chromosome, telomeric region
GO:0000783	nuclear telomere cap complex
GO:0005654	nucleoplasm
GO:0005697	telomerase holoenzyme complex
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0016605	PML body