Version 5.4
Homo sapiens Protein: LEF1
Summary
InnateDB Protein IDBP-474271.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LEF1
Protein Name lymphoid enhancer-binding factor 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000427459
InnateDB Gene IDBG-33529 (LEF1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 68 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Experimentally validated
Total 68 [view]
Protein-Protein 59 [view]
Protein-DNA 9 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008013 beta-catenin binding
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0016055 Wnt signaling pathway
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR013558 CTNNB1 binding, N-teminal
PFAM PF08347
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL D6RID7
UniProt Splice Variant
Entrez Gene 51176
UniGene Hs.743478
RefSeq
HUGO HGNC:6551
OMIM 153245
CCDS
HPRD 01075
IMGT
EMBL AC092539 AC097067 AC118062 AC123576
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca