InnateDB Protein
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IDBP-474343.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TNPO1
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Protein Name
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transportin 1
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Synonyms
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IPO2; KPNB2; MIP; MIP1; TRN;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000428899
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InnateDB Gene
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IDBG-27793 (TNPO1)
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Protein Structure
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Function |
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear import of M9- containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Appears also to be involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones, and SRP19. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Mediates nuclear import of ADAR/ADAR1 (isoform 5) in a RanGTP-dependent manner. {ECO:0000250, ECO:0000269PubMed:11682607, ECO:0000269PubMed:19124606, ECO:0000269PubMed:8986607, ECO:0000269PubMed:9687515}.
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Subcellular Localization |
Cytoplasm. Nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
51
[view]
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Protein-Protein |
49
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000357
HEAT
IPR016024
Armadillo-type fold
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PFAM |
PF02985
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q92973
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PhosphoSite |
PhosphoSite-Q92973
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TrEMBL |
S4R398
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UniProt Splice Variant |
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Entrez Gene |
3842
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UniGene |
Hs.640555
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RefSeq |
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HUGO |
HGNC:6401
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OMIM |
602901
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CCDS |
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HPRD |
04210
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IMGT |
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EMBL |
AC008953
AC008972
AC035140
AK301021
BC040340
U70322
U72069
U72395
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GenPept |
AAB58254
AAB68948
AAC50723
AAH40340
BAG62638
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