InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PHC3

Summary

InnateDB Protein

IDBP-474404.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PHC3

Protein Name

polyhomeotic homolog 3 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000420454

InnateDB Gene

IDBG-64379 (PHC3)

Protein Structure

UniProt Annotation

Function

Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269PubMed:12167701}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:12167701, ECO:0000269PubMed:21282530}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0008270	zinc ion binding

Biological Process

GO:0007275

multicellular organismal development

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0015629	actin cytoskeleton
GO:0031519	PcG protein complex
GO:0035102	PRC1 complex
GO:0043231	intracellular membrane-bounded organelle