Version 5.4
Homo sapiens Protein: CNOT7
Summary
InnateDB Protein IDBP-474554.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CNOT7
Protein Name CCR4-NOT transcription complex, subunit 7
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000429093
InnateDB Gene IDBG-8558 (CNOT7)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 47 [view]
Protein-Protein 46 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000175 3'-5'-exoribonuclease activity
GO:0003676 nucleic acid binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003723 RNA binding
GO:0004532 exoribonuclease activity
GO:0004535 poly(A)-specific ribonuclease activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0005975 carbohydrate metabolic process
GO:0006351 transcription, DNA-templated
GO:0006417 regulation of translation
GO:0007165 signal transduction
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0031047 gene silencing by RNA
GO:0035195 gene silencing by miRNA
GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic
GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
GO:0005634 nucleus
GO:0005829 cytosol
GO:0016020 membrane
GO:0030014 CCR4-NOT complex
Protein Structure and Domains
PDB ID
InterPro IPR006941 Ribonuclease CAF1
IPR012337 Ribonuclease H-like domain
PFAM PF04857
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UIV1
PhosphoSite PhosphoSite-Q9UIV1
TrEMBL E5RJE0
UniProt Splice Variant
Entrez Gene 29883
UniGene Hs.711543
RefSeq NP_473367
HUGO HGNC:14101
OMIM 604913
CCDS CCDS55202
HPRD
IMGT
EMBL AC091050 AF086915 AK021808 AK023466 BC060852 BC070187 CH471080 L46722
GenPept AAF01500 AAH60852 AAH70187 AAP97145 BAG51053 BAG51197 EAW63820 EAW63821 EAW63822 EAW63823

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca