InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BRCA1

Summary

InnateDB Protein

IDBP-474712.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BRCA1

Protein Name

breast cancer 1, early onset

Synonyms

BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PPP1R53; PSCP; RNF53;

Species

Homo sapiens

Ensembl Protein

ENSP00000418548

InnateDB Gene

IDBG-52172 (BRCA1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 625 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	625 [view]
Protein-Protein	603 [view]
Protein-DNA	15 [view]
Protein-RNA	0
DNA-DNA	7 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003713	transcription coactivator activity
GO:0003723	RNA binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0015631	tubulin binding
GO:0016874	ligase activity
GO:0019899	enzyme binding
GO:0031625	ubiquitin protein ligase binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding
GO:0050681	androgen receptor binding

Biological Process

GO:0000724	double-strand break repair via homologous recombination
GO:0006281	DNA repair
GO:0006301	postreplication repair
GO:0006302	double-strand break repair
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006359	regulation of transcription from RNA polymerase III promoter
GO:0006633	fatty acid biosynthetic process
GO:0006915	apoptotic process
GO:0006974	cellular response to DNA damage stimulus
GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007059	chromosome segregation
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010212	response to ionizing radiation
GO:0016567	protein ubiquitination
GO:0030521	androgen receptor signaling pathway
GO:0031398	positive regulation of protein ubiquitination
GO:0031572	G2 DNA damage checkpoint
GO:0034446	substrate adhesion-dependent cell spreading
GO:0035066	positive regulation of histone acetylation
GO:0042127	regulation of cell proliferation
GO:0042981	regulation of apoptotic process
GO:0043627	response to estrogen
GO:0045717	negative regulation of fatty acid biosynthetic process
GO:0045739	positive regulation of DNA repair
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046600	negative regulation of centriole replication
GO:0051571	positive regulation of histone H3-K4 methylation
GO:0051573	negative regulation of histone H3-K9 methylation
GO:0051865	protein autoubiquitination
GO:0070512	positive regulation of histone H4-K20 methylation
GO:0071158	positive regulation of cell cycle arrest
GO:0071681	cellular response to indole-3-methanol
GO:0085020	protein K6-linked ubiquitination
GO:2000145	regulation of cell motility
GO:2000617	positive regulation of histone H3-K9 acetylation
GO:2000620	positive regulation of histone H4-K16 acetylation

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0001726	ruffle
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005694	chromosome
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0008274	gamma-tubulin ring complex
GO:0030529	ribonucleoprotein complex
GO:0031436	BRCA1-BARD1 complex
GO:0031941	filamentous actin
GO:0043234	protein complex
GO:0070531	BRCA1-A complex