InnateDB Protein
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IDBP-474805.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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GCNT2
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Protein Name
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glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
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Synonyms
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bA360O19.2; bA421M1.1; CCAT; CTRCT13; GCNT2C; GCNT5; IGNT; II; NACGT1; NAGCT1; ULG3;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000419411
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InnateDB Gene
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IDBG-60908 (GCNT2)
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Protein Structure
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Function |
Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells. The expression of the blood group I antigen in erythrocytes is determined by isoform C.
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Subcellular Localization |
Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Isoform B is expressed in lens epithelium cells. Isoform C is expressed in reticulocytes. {ECO:0000269PubMed:12424189}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0008109
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N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity
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GO:0008375
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acetylglucosaminyltransferase activity
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Biological Process |
GO:0006486
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protein glycosylation
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GO:0007179
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transforming growth factor beta receptor signaling pathway
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GO:0008284
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positive regulation of cell proliferation
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GO:0010608
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posttranscriptional regulation of gene expression
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GO:0010718
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positive regulation of epithelial to mesenchymal transition
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GO:0010812
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negative regulation of cell-substrate adhesion
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GO:0030335
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positive regulation of cell migration
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GO:0034116
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positive regulation of heterotypic cell-cell adhesion
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GO:0036438
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maintenance of lens transparency
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GO:0051897
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positive regulation of protein kinase B signaling
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GO:0070374
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positive regulation of ERK1 and ERK2 cascade
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Cellular Component |
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PDB ID |
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InterPro |
IPR003406
Glycosyl transferase, family 14
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PFAM |
PF02485
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8N0V5
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PhosphoSite |
PhosphoSite-
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TrEMBL |
Q8N7N7
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UniProt Splice Variant |
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Entrez Gene |
2651
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UniGene |
Hs.519884
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RefSeq |
NP_663624
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HUGO |
HGNC:4204
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OMIM |
600429
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CCDS |
CCDS34338
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HPRD |
02695
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IMGT |
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EMBL |
AB078432
AF458024
AK090483
AK098105
AK291767
AL139039
AL358777
AY435145
CH471087
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GenPept |
AAM73864
AAR95646
BAC03464
BAC05234
BAC66781
BAF84456
CAQ52588
CAQ52597
EAW55262
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