InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTTG1

Summary

InnateDB Protein

IDBP-474832.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTTG1

Protein Name

pituitary tumor-transforming 1

Synonyms

EAP1; HPTTG; PTTG; TUTR1;

Species

Homo sapiens

Ensembl Protein

ENSP00000430642

InnateDB Gene

IDBG-56181 (PTTG1)

Protein Structure

UniProt Annotation

Function

Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation. {ECO:0000269PubMed:10411507, ECO:0000269PubMed:11238996, ECO:0000269PubMed:11371342, ECO:0000269PubMed:12355087}.

Subcellular Localization

Cytoplasm. Nucleus.

Disease Associations

Tissue Specificity

Expressed at low level in most tissues, except in adult testis, where it is highly expressed. Overexpressed in many patients suffering from pituitary adenomas, primary epithelial neoplasias, and esophageal cancer. {ECO:0000269PubMed:9811450}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.

Experimentally validated
Total	56 [view]
Protein-Protein	51 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004869	cysteine-type endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0017124	SH3 domain binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0006281	DNA repair
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division
GO:0007283	spermatogenesis
GO:0010951	negative regulation of endopeptidase activity
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0051276	chromosome organization