InnateDB Protein
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IDBP-475652.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PHC3
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Protein Name
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polyhomeotic homolog 3 (Drosophila)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000418266
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InnateDB Gene
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IDBG-64379 (PHC3)
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Protein Structure
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Function |
Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269PubMed:12167701}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:12167701, ECO:0000269PubMed:21282530}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
27
[view]
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Protein-Protein |
27
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8NDX5
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PhosphoSite |
PhosphoSite-Q8NDX5
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
80012
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UniGene |
Hs.738779
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RefSeq |
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HUGO |
HGNC:15682
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OMIM |
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CCDS |
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HPRD |
10149
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IMGT |
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EMBL |
AC008040
AC023891
AF380154
AF444193
AJ320486
AK022791
AK023029
BC022325
BC070164
BC131772
BX647868
CH471052
EF560717
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GenPept |
AAH22325
AAH70164
AAI31773
AAM46139
AAM51781
BAB14245
BAB14365
CAC86587
CAI46090
EAW78519
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