InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLU7

Summary

InnateDB Protein

IDBP-475969.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLU7

Protein Name

SLU7 splicing factor homolog (S. cerevisiae)

Synonyms

9G8; hSlu7;

Species

Homo sapiens

Ensembl Protein

ENSP00000428362

InnateDB Gene

IDBG-56099 (SLU7)

Protein Structure

UniProt Annotation

Function

Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'- splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. {ECO:0000269PubMed:10197984, ECO:0000269PubMed:10647016, ECO:0000269PubMed:12764196, ECO:0000269PubMed:15728250}.

Subcellular Localization

Nucleus. Cytoplasm. Note=Predominantly nuclear. Shuttling between the nucleus and the cytoplasm is regulated by the CCHC-type zinc finger. Upon UV-C stress stimulus, the nuclear concentration of the protein decreases, affecting alternative splicing. Translocates from the nucleus to the cytoplasm after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	36 [view]
Protein-Protein	34 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000386	second spliceosomal transesterification activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0030628	pre-mRNA 3'-splice site binding

Biological Process

GO:0000375	RNA splicing, via transesterification reactions
GO:0000380	alternative mRNA splicing, via spliceosome
GO:0000389	mRNA 3'-splice site recognition
GO:0000398	mRNA splicing, via spliceosome
GO:0006886	intracellular protein transport
GO:0034605	cellular response to heat

Cellular Component

GO:0005634	nucleus
GO:0005681	spliceosomal complex
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0016607	nuclear speck
GO:0030532	small nuclear ribonucleoprotein complex
GO:0043231	intracellular membrane-bounded organelle
GO:0071013	catalytic step 2 spliceosome