Version 5.4
Homo sapiens Protein: PHC3
Summary
InnateDB Protein IDBP-476052.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PHC3
Protein Name polyhomeotic homolog 3 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000420294
InnateDB Gene IDBG-64379 (PHC3)
Protein Structure
UniProt Annotation
Function Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269PubMed:12167701}.
Subcellular Localization Nucleus {ECO:0000269PubMed:12167701, ECO:0000269PubMed:21282530}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 27 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0007275 multicellular organismal development
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0015629 actin cytoskeleton
GO:0031519 PcG protein complex
GO:0035102 PRC1 complex
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro IPR001660 Sterile alpha motif domain
IPR011510 Sterile alpha motif, type 2
IPR012313 Zinc finger, FCS-type
IPR013761 Sterile alpha motif/pointed domain
IPR021129 Sterile alpha motif, type 1
PFAM PF07647
PF00536
PRINTS
PIRSF
SMART SM00454
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NDX5
PhosphoSite PhosphoSite-Q8NDX5
TrEMBL C9JYH7
UniProt Splice Variant
Entrez Gene 80012
UniGene Hs.738779
RefSeq NP_079223
HUGO HGNC:15682
OMIM
CCDS CCDS46952
HPRD 10149
IMGT
EMBL AC008040 AC023891 AF380154 AF444193 AJ320486 AK022791 AK023029 BC022325 BC070164 BC131772 BX647868 CH471052 EF560717
GenPept AAH22325 AAH70164 AAI31773 AAM46139 AAM51781 BAB14245 BAB14365 CAC86587 CAI46090 EAW78519

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca