InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BRCA1

Summary

InnateDB Protein

IDBP-476394.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BRCA1

Protein Name

breast cancer 1, early onset

Synonyms

BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PPP1R53; PSCP; RNF53;

Species

Homo sapiens

Ensembl Protein

ENSP00000418775

InnateDB Gene

IDBG-52172 (BRCA1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 625 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	625 [view]
Protein-Protein	603 [view]
Protein-DNA	15 [view]
Protein-RNA	0
DNA-DNA	7 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004842	ubiquitin-protein transferase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006281	DNA repair
GO:0016567	protein ubiquitination

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001357 BRCT domain
IPR011364 Breast cancer type 1 susceptibility protein (BRCA1)

PFAM

PF00533
PF12738

PRINTS

PR00493

PIRSF

PIRSF001734

SMART

SM00292

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q9UE29

UniProt Splice Variant

Entrez Gene

672

UniGene

Hs.622171

RefSeq

NP_009228

HUGO

HGNC:1100

OMIM

113705

CCDS

CCDS11459

HPRD

00218

IMGT

EMBL

AC135721 AF284812 AF507076 AF507078 AY093485 AY093486 AY093487 AY093489 AY093490 AY093493 DQ116737 DQ145822 DQ145825 DQ145826 DQ299305 DQ299306 DQ299307 DQ299308 DQ299309 DQ299310 DQ299311 DQ299312 DQ299313 DQ299314 DQ299315 DQ299321 DQ299322 DQ299323 DQ299324 DQ299325 DQ299326 DQ299327 DQ299328 DQ299329 DQ299330 DQ299331 FJ940752 HE600032 HE600033 HE600034 HE600035 HE600036 HE600037 HE600038 JX480460 JX480462 JX480466 U68041 Y08757

GenPept

AAB08105 AAF97939 AAM18219 AAM18220 AAM18221 AAM18222 AAM18223 AAM18226 AAN61423 AAN61425 AAZ16492 AAZ79406 AAZ79409 AAZ79410 ABB87053 ABB87054 ABB87055 ABB87056 ABB87057 ABB87058 ABB87059 ABB87060 ABB87061 ABB87062 ABB87063 ABB87069 ABB87070 ABB87071 ABB87072 ABB87073 ABB87074 ABB87075 ABB87076 ABB87077 ABB87078 ABB87079 ACR33809 AFU88802 AFU88804 AFU88808 CAA70003 CCD57768 CCD57769 CCD57770 CCD57771 CCD57772 CCD57773 CCD57774