InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ASAP1

Summary

InnateDB Protein

IDBP-476504.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ASAP1

Protein Name

ArfGAP with SH3 domain, ankyrin repeat and PH domain 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000429900

InnateDB Gene

IDBG-35667 (ASAP1)

Protein Structure

UniProt Annotation

Function

Possesses phosphatidylinositol 4,5-bisphosphate- dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types (By similarity). Plays a role in ciliogenesis. {ECO:0000250, ECO:0000269PubMed:20393563}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Note=Predominantly cytoplasmic. Partially membrane- associated. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	50 [view]
Protein-Protein	50 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008060	ARF GTPase activator activity
GO:0008270	zinc ion binding

Biological Process

GO:0032312	regulation of ARF GTPase activity
GO:0043547	positive regulation of GTPase activity
GO:0060271	cilium morphogenesis

Cellular Component

GO:0005737	cytoplasm
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001164 Arf GTPase activating protein
IPR001452 SH3 domain
IPR001849 Pleckstrin homology domain
IPR002110 Ankyrin repeat
IPR011511 Variant SH3 domain
IPR020683 Ankyrin repeat-containing domain

PFAM