Version 5.4
Homo sapiens Protein: NDRG1
Summary
InnateDB Protein IDBP-476514.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NDRG1
Protein Name N-myc downstream regulated 1
Synonyms CAP43; CMT4D; DRG-1; DRG1; GC4; HMSNL; NDR1; NMSL; PROXY1; RIT42; RTP; TARG1; TDD5;
Species Homo sapiens
Ensembl Protein ENSP00000427894
InnateDB Gene IDBG-36420 (NDRG1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 92 experimentally validated interaction(s) in this database.
Experimentally validated
Total 92 [view]
Protein-Protein 87 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0017137 Rab GTPase binding
GO:0043015 gamma-tubulin binding
GO:0045296 cadherin binding
Biological Process
GO:0008219 cell death
GO:0010038 response to metal ion
GO:0030330 DNA damage response, signal transduction by p53 class mediator
GO:0071456 cellular response to hypoxia
GO:0090232 positive regulation of spindle checkpoint
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0005913 cell-cell adherens junction
GO:0015630 microtubule cytoskeleton
GO:0048471 perinuclear region of cytoplasm
GO:0055038 recycling endosome membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000073 Alpha/beta hydrolase fold-1
IPR004142 NDRG
IPR029058 Alpha/Beta hydrolase fold
PFAM PF00561
PF03096
PRINTS PR00111
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q92597
PhosphoSite PhosphoSite-Q92597
TrEMBL E5RGG6
UniProt Splice Variant
Entrez Gene 10397
UniGene Hs.613170
RefSeq NP_001245361
HUGO HGNC:7679
OMIM 605262
CCDS CCDS59113
HPRD 05586
IMGT
EMBL AF004162 AF186190 AF192304 AF230380 AK091147 AK124709 AK126924 AK296794 AK298236 BC003175 CH471060 CR456842 D87953 X92845
GenPept AAC13419 AAF71305 AAH03175 BAA13505 BAG52292 BAG54074 BAG54400 BAH12432 BAH12741 CAA63430 CAG33123 EAW92164

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca