InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DPPA2

Summary

InnateDB Protein

IDBP-476574.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DPPA2

Protein Name

developmental pluripotency associated 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000417710

InnateDB Gene

IDBG-49290 (DPPA2)

Protein Structure

UniProt Annotation

Function

Binds to target gene promoters, including NKX2-5 and SYCE1, but not GATA4, and may be involved in the maintenance of the active epigenetic status of these genes. {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:15583978}.

Disease Associations

Tissue Specificity

Expressed in embryonic stem cells. No expression is seen in 5 months embryo, mesenchymal stem cells, embryonic fibrocytes and adult tissues. {ECO:0000269PubMed:15583978}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003682	chromatin binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0019827	stem cell maintenance
GO:0031060	regulation of histone methylation
GO:0060484	lung-associated mesenchyme development
GO:2000648	positive regulation of stem cell proliferation