InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FBLN2

Summary

InnateDB Protein

IDBP-476672.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FBLN2

Protein Name

fibulin 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000420042

InnateDB Gene

IDBG-19758 (FBLN2)

Protein Structure

UniProt Annotation

Function

Its binding to fibronectin and some other ligands is calcium dependent.

Subcellular Localization

Secreted, extracellular space, extracellular matrix.

Disease Associations

Tissue Specificity

Component of both basement membranes and other connective tissues. Expressed in heart, placenta and ovary.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005201	extracellular matrix structural constituent
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0030198

extracellular matrix organization

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000020 Anaphylatoxin/fibulin
IPR000742 Epidermal growth factor-like domain
IPR001881 EGF-like calcium-binding domain
IPR018081 Anaphylatoxin, complement system

PFAM

PF01821
PF00008
PF07645

PRINTS

PIRSF

SMART

SM00104
SM00181
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P98095