InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DDX41

Summary

InnateDB Protein

IDBP-476793.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DDX41

Protein Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 41

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000422753

InnateDB Gene

IDBG-60413 (DDX41)

Protein Structure

UniProt Annotation

Function

Probable ATP-dependent RNA helicase. Is required during post-transcriptional gene expression. May be involved in pre-mRNA splicing.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	20 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006396	RNA processing
GO:0006915	apoptotic process
GO:0007275	multicellular organismal development
GO:0032479	regulation of type I interferon production
GO:0032481	positive regulation of type I interferon production
GO:0035458	cellular response to interferon-beta
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051607	defense response to virus

Cellular Component

GO:0005634	nucleus
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0016020	membrane
GO:0071013	catalytic step 2 spliceosome

Protein Structure and Domains

PDB ID

InterPro

IPR001650 Helicase, C-terminal
IPR001878 Zinc finger, CCHC-type
IPR011545 DEAD/DEAH box helicase domain
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR014014 RNA helicase, DEAD-box type, Q motif
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF00098
PF00270

PRINTS

PIRSF

SMART

SM00490
SM00343
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9UJV9