InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EGR3

Summary

InnateDB Protein

IDBP-476970.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EGR3

Protein Name

early growth response 3

Synonyms

EGR-3; PILOT;

Species

Homo sapiens

Ensembl Protein

ENSP00000430310

InnateDB Gene

IDBG-11219 (EGR3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	0
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0046872	metal ion binding

Biological Process

GO:0001938	positive regulation of endothelial cell proliferation
GO:0002042	cell migration involved in sprouting angiogenesis
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007517	muscle organ development
GO:0007623	circadian rhythm
GO:0035767	endothelial cell chemotaxis
GO:0035924	cellular response to vascular endothelial growth factor stimulus
GO:0043066	negative regulation of apoptotic process
GO:0044344	cellular response to fibroblast growth factor stimulus
GO:0071320	cellular response to cAMP
GO:0071371	cellular response to gonadotropin stimulus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
IPR021849 Protein of unknown function DUF3446

PFAM

PF00096
PF11928

PRINTS

PIRSF

SMART

SM00355

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-Q06889

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AC105046 AK292464 AK294968 AK295134 AK313604 BC104765 BC112279 S40832 X63741

GenPept

AAB19317 AAI04766 AAI12280 BAF85153 BAG36369 BAG58041 BAG58157 CAA45275

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca