Version 5.4
Homo sapiens Protein: TP53
Summary
InnateDB Protein IDBP-477072.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TP53
Protein Name tumor protein p53
Synonyms BCC7; LFS1; P53; TRP53;
Species Homo sapiens
Ensembl Protein ENSP00000423862
InnateDB Gene IDBG-26364 (TP53)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1328 experimentally validated interaction(s) in this database.
They are also associated with 85 interaction(s) predicted by orthology.
Experimentally validated
Total 1328 [view]
Protein-Protein 1244 [view]
Protein-DNA 66 [view]
Protein-RNA 0
DNA-DNA 18 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 85 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0044212 transcription regulatory region DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006915 apoptotic process
GO:0007049 cell cycle
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR002117 p53 tumour suppressor family
IPR008967 p53-like transcription factor, DNA-binding
IPR011615 p53, DNA-binding domain
IPR013872 p53 transactivation domain
PFAM PF00870
PF08563
PRINTS PR00386
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q761V2
UniProt Splice Variant
Entrez Gene 7157
UniGene Hs.743051
RefSeq
HUGO HGNC:11998
OMIM 191170
CCDS
HPRD 01859
IMGT
EMBL AB118156 AC007421 AC087388 DQ486039 EF178467 EF178468 EF445599 EF445600 EF445601 EF445602 EF445603 EF445604 EF445605 EF445606 EF445607 EF445608 EF445609 EF445610 EF445611 EF445612 EF445613 EF445614 EF445615 EF445616 EF445617 EF445618 EF445619 EF445620 EF445621 EF445622 EF445623 EF445624 EF445625 EF445626 EF680844 EU523098 JF923570 JF923571 JQ751621 JQ751622 JQ751623 JQ751624 JQ751626 JQ751627 JQ751628 JQ751629 JQ751630 JQ751631 JQ751632 JQ751633 JQ751634 JQ751635 JQ751636 JQ751637 JQ751638 JQ751639 JQ751640 JQ751641 JQ751642 JQ751643 JQ751644 JQ751645 JQ751646 JQ751647 JQ751648 JQ751650 JQ751651 JQ751652 JQ751654 JQ751655 JQ751656 JQ751657 JQ751658 JQ751659 JQ751660 JQ751661 JQ751662 JQ751663 JQ751664 JQ751665 JQ751666 JQ751667 JQ751668 JQ751669 JQ751670 JQ751671 JQ751672 JQ751673 JQ751674 JQ751675 JQ751676 JQ751677 JQ751678 JQ751679 JQ751680 JQ751681 JQ751682 JQ751683 JQ751684 JQ751685 JQ751686 JQ751687 JQ751688 JQ751689 JQ751690 JQ751691 JQ751692 JQ751693 JQ751694 JQ751695 JQ751696 JQ751697 JQ751698 JQ751699 JQ751700 JQ751701 JQ751702 JQ751703 JQ751704 JQ751705 JQ751706 JQ751707 JQ751708 JQ751709 JQ751710 JQ751711 JQ751712 JQ751713 JQ751714 JQ751715 JQ751716 JQ751717 JQ751718 JQ751719 JQ751720 JQ751721 JQ751722 JQ751723 JQ751724 JQ751725 JQ751726 JQ751727 JQ751728 JQ751729 JQ751730 JQ751731 JQ751732 JQ751733 JQ751734 JQ751735 JQ751736 JQ751737 JQ751738 JQ751739 JQ751740 JQ751741 JQ751742 JQ751743 JQ751744 JQ751745 JQ751746 JQ751747 JQ751748 JQ751749 JQ751750 JQ751751 JQ751752 JQ751753 JQ751754 JQ751755 JQ751756 JQ751757 JQ751758 JQ751759 JQ751760 JQ751761 JQ751762 JQ751763 JQ751764 JQ751765 JQ751766 JQ751767 JQ751768 JQ751769 JQ751770 JQ751771 JQ751772 JQ751773 JQ751774 JQ751775 JQ751776 JQ751777 JQ751778 JQ751779 JQ751780 JQ751781 JQ751782 JQ751783 JQ751784 JQ751785 JQ751786 JQ751787 JQ751788 JQ751789 JQ751790 JQ751791 JQ751792 JQ751793 JQ751794 JQ751795 JQ751796 JQ751797 JQ751798 JQ751799 JQ751800 JQ751802 JQ751803 JQ751805 JQ751806 JQ751808 JQ751810 JQ751813 JQ751814 JQ751815 JQ751816 JQ751818 JQ751819 JQ751820 JQ751822 JQ751824 JQ751825 JQ751826 JQ751827 JQ751828 JQ751829 JQ751831 JQ751833 JQ751834 JQ751835 JQ751836 JQ751839 JQ751840 JQ751841 JQ751842 JQ751843 JQ751844 JQ751845 JQ751847 JQ751848 JQ751849 JQ751850 JQ751851 JQ751852 JQ751853 JQ751854 JQ751855 JQ751856 JQ751857 JQ751858 JQ751859 JQ751860 JQ751861 JQ751862 JQ751863 JQ751864 JQ751865 JQ751866 JQ751867 JQ751868 JQ751869 JQ751870 JQ751871 JQ751872 JQ751873 JQ751874 JQ751875 JQ751876 JQ751877 JQ751878 JQ751879 JQ751880 JQ751881 JQ751882 JQ751883 JQ751884 JQ751885 JQ751886 JQ751887 JQ751888 JQ751889 JQ751890 JQ751891 JQ751892 JQ751893 JQ751894 JQ751895 JQ751896 JQ751897 JQ751898 JQ751899 JQ751900 JQ751901 JQ751902 JQ751903 JQ751904 JQ751905 JQ751906 JQ751907 JQ751908 JQ751909 JQ751910 JQ751911 JQ751912 JQ751913 JQ751914 JQ751915 JQ751916 JQ751917 JQ751918 JQ751919 JQ751920 JQ751921 JQ751922
GenPept ABF51618 ABM69023 ABM69024 ABO28412 ABO28413 ABO28414 ABO28415 ABO28416 ABO28417 ABO28418 ABO28419 ABO28420 ABO28421 ABO28422 ABO28423 ABO28424 ABO28425 ABO28426 ABO28427 ABO28428 ABO28429 ABO28430 ABO28431 ABO28432 ABO28433 ABO28434 ABO28435 ABO28436 ABO28437 ABO28438 ABO28439 ABV21351 ACA63978 AEQ16483 AEQ16484 AGA62828 AGA62829 AGA62830 AGA62831 AGA62833 AGA62834 AGA62835 AGA62836 AGA62837 AGA62838 AGA62839 AGA62840 AGA62841 AGA62842 AGA62843 AGA62844 AGA62845 AGA62846 AGA62847 AGA62848 AGA62849 AGA62850 AGA62851 AGA62852 AGA62853 AGA62854 AGA62855 AGA62857 AGA62858 AGA62859 AGA62861 AGA62862 AGA62863 AGA62864 AGA62865 AGA62866 AGA62867 AGA62868 AGA62869 AGA62870 AGA62871 AGA62872 AGA62873 AGA62874 AGA62875 AGA62876 AGA62877 AGA62878 AGA62879 AGA62880 AGA62881 AGA62882 AGA62883 AGA62884 AGA62885 AGA62886 AGA62887 AGA62888 AGA62889 AGA62890 AGA62891 AGA62892 AGA62893 AGA62894 AGA62895 AGA62896 AGA62897 AGA62898 AGA62899 AGA62900 AGA62901 AGA62902 AGA62903 AGA62904 AGA62905 AGA62906 AGA62907 AGA62908 AGA62909 AGA62910 AGA62911 AGA62912 AGA62913 AGA62914 AGA62915 AGA62916 AGA62917 AGA62918 AGA62919 AGA62920 AGA62921 AGA62922 AGA62923 AGA62924 AGA62925 AGA62926 AGA62927 AGA62928 AGA62929 AGA62930 AGA62931 AGA62932 AGA62933 AGA62934 AGA62935 AGA62936 AGA62937 AGA62938 AGA62939 AGA62940 AGA62941 AGA62942 AGA62943 AGA62944 AGA62945 AGA62946 AGA62947 AGA62948 AGA62949 AGA62950 AGA62951 AGA62952 AGA62953 AGA62954 AGA62955 AGA62956 AGA62957 AGA62958 AGA62959 AGA62960 AGA62961 AGA62962 AGA62963 AGA62964 AGA62965 AGA62966 AGA62967 AGA62968 AGA62969 AGA62970 AGA62971 AGA62972 AGA62973 AGA62974 AGA62975 AGA62976 AGA62977 AGA62978 AGA62979 AGA62980 AGA62981 AGA62982 AGA62983 AGA62984 AGA62985 AGA62986 AGA62987 AGA62988 AGA62989 AGA62990 AGA62991 AGA62992 AGA62993 AGA62994 AGA62995 AGA62996 AGA62997 AGA62998 AGA62999 AGA63000 AGA63001 AGA63002 AGA63003 AGA63004 AGA63005 AGA63006 AGA63007 AGA63008 AGA63009 AGA63011 AGA63012 AGA63014 AGA63016 AGA63019 AGA63020 AGA63021 AGA63022 AGA63024 AGA63025 AGA63026 AGA63028 AGA63030 AGA63031 AGA63032 AGA63033 AGA63034 AGA63035 AGA63037 AGA63039 AGA63040 AGA63041 AGA63042 AGA63045 AGA63046 AGA63047 AGA63048 AGA63049 AGA63050 AGA63051 AGA63053 AGA63054 AGA63055 AGA63056 AGA63057 AGA63058 AGA63059 AGA63060 AGA63061 AGA63062 AGA63063 AGA63064 AGA63065 AGA63066 AGA63067 AGA63068 AGA63069 AGA63070 AGA63071 AGA63072 AGA63073 AGA63074 AGA63075 AGA63076 AGA63077 AGA63078 AGA63079 AGA63080 AGA63081 AGA63082 AGA63083 AGA63084 AGA63085 AGA63086 AGA63087 AGA63088 AGA63089 AGA63090 AGA63091 AGA63092 AGA63093 AGA63094 AGA63095 AGA63096 AGA63097 AGA63098 AGA63099 AGA63100 AGA63101 AGA63102 AGA63103 AGA63104 AGA63105 AGA63106 AGA63107 AGA63108 AGA63109 AGA63110 AGA63111 AGA63112 AGA63113 AGA63114 AGA63115 AGA63116 AGA63117 AGA63118 AGA63119 AGA63120 AGA63121 AGA63122 AGA63123 AGA63124 AGA63125 AGA63126 AGA63127 AGA63128 BAD11806

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca