InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLTP

Summary

InnateDB Protein

IDBP-477077.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLTP

Protein Name

phospholipid transfer protein

Synonyms

BPIFE; HDLCQ9;

Species

Homo sapiens

Ensembl Protein

ENSP00000417138

InnateDB Gene

IDBG-78556 (PLTP)

Protein Structure

UniProt Annotation

Function

Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine. Essential for the transfer of excess surface lipids from triglyceride-rich lipoproteins to HDL, thereby facilitating the formation of smaller lipoprotein remnants, contributing to the formation of LDL, and assisting in the maturation of HDL particles. PLTP also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion. Two distinct forms of PLTP exist in plasma: an active form that can transfer PC from phospholipid vesicles to high-density lipoproteins (HDL), and an inactive form that lacks this capability.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Wide tissue distribution. Placenta > pancreas > lung > kidney > heart > liver > skeletal muscle > brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008289	lipid binding

Biological Process

GO:0006629	lipid metabolic process
GO:0006869	lipid transport
GO:0010189	vitamin E biosynthetic process
GO:0030317	sperm motility
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space

Protein Structure and Domains

PDB ID

InterPro

IPR001124 Lipid-binding serum glycoprotein, C-terminal
IPR017942 Lipid-binding serum glycoprotein, N-terminal
IPR017943 Bactericidal permeability-increasing protein, alpha/beta domain

PFAM

PF02886
PF01273

PRINTS

PIRSF

SMART

SM00329
SM00328

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P55058