InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GNGT2

Summary

InnateDB Protein

IDBP-477097.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GNGT2

Protein Name

guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2

Synonyms

G-GAMMA-8; G-GAMMA-C; GNG8; GNG9; GNGT8;

Species

Homo sapiens

Ensembl Protein

ENSP00000426022

InnateDB Gene

IDBG-57490 (GNGT2)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction.

Subcellular Localization

Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.

Disease Associations

Tissue Specificity

Retinal cones.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0004871	signal transducer activity

Biological Process

GO:0006184	GTP catabolic process
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007268	synaptic transmission
GO:0007602	phototransduction

Cellular Component

GO:0005834	heterotrimeric G-protein complex
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001770 G-protein, gamma subunit
IPR015898 G-protein gamma-like domain

PFAM

PF00631

PRINTS

PR00321

PIRSF

SMART

SM00224

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AF001159 AF001160 AF365870 AF493876 AK312839 BC008663 CH471109

GenPept

AAB70039 AAH08663 AAK53384 AAM12590 BAG35693 EAW94688 EAW94689

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca