InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCNL1

Summary

InnateDB Protein

IDBP-477228.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCNL1

Protein Name

cyclin L1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000417343

InnateDB Gene

IDBG-62795 (CCNL1)

Protein Structure

UniProt Annotation

Function

Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases (CDKs) and has a role in the second step of splicing. May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC). Inhibited by the CDK-specific inhibitor p21. {ECO:0000269PubMed:11980906, ECO:0000269PubMed:12414649, ECO:0000269PubMed:15700036}.

Subcellular Localization

Nucleus speckle {ECO:0000250}. Note=More specifically found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous with higher level in thymus. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC). {ECO:0000269PubMed:11980906, ECO:0000269PubMed:12414649, ECO:0000269PubMed:15700036}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0019901	protein kinase binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006396	RNA processing