Version 5.4
Homo sapiens Protein: PSEN2
Summary
InnateDB Protein IDBP-477429.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PSEN2
Protein Name presenilin 2 (Alzheimer disease 4)
Synonyms AD3L; AD4; CMD1V; PS2; STM2;
Species Homo sapiens
Ensembl Protein ENSP00000427806
InnateDB Gene IDBG-107053 (PSEN2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 77 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 77 [view]
Protein-Protein 73 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0035556 intracellular signal transduction
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001108 Peptidase A22A, presenilin
IPR001493 Peptidase A22A, presenilin 2
IPR006639 Presenilin/signal peptide peptidase
PFAM PF01080
PRINTS PR01072
PR01074
PIRSF
SMART SM00730
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E5RG63
UniProt Splice Variant
Entrez Gene 5664
UniGene Hs.25363
RefSeq
HUGO HGNC:9509
OMIM 600759
CCDS
HPRD 02860
IMGT
EMBL AL359732 AL391628
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca