InnateDB Protein
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IDBP-477595.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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U2AF1
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Protein Name
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U2 small nuclear RNA auxiliary factor 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000420672
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InnateDB Gene
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IDBG-4654 (U2AF1)
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Protein Structure
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Function |
Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron. {ECO:0000269PubMed:8647433}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:15096518}. Nucleus speckle {ECO:0000269PubMed:15096518}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 139 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
139
[view]
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Protein-Protein |
138
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000571
Zinc finger, CCCH-type
IPR009145
U2 auxiliary factor small subunit
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PFAM |
PF00642
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PRINTS |
PR01848
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PIRSF |
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SMART |
SM00356
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TIGRFAMs |
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Modification |
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SwissProt |
Q01081
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PhosphoSite |
PhosphoSite-Q01081
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
7307
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UniGene |
Hs.738829
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RefSeq |
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HUGO |
HGNC:12453
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OMIM |
191317
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CCDS |
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HPRD |
01871
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IMGT |
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EMBL |
AF370386
AJ627978
AP001631
AP001748
BC001177
BC001923
CH471079
M96982
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GenPept |
AAA36619
AAH01177
AAH01923
AAQ15222
BAA95534
CAF29556
EAX09501
EAX09502
EAX09504
EAX09505
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