InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NCK1

Summary

InnateDB Protein

IDBP-477840.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NCK1

Protein Name

NCK adaptor protein 1

Synonyms

NCK; nck-1; NCKalpha;

Species

Homo sapiens

Ensembl Protein

ENSP00000417273

InnateDB Gene

IDBG-58017 (NCK1)

Protein Structure

UniProt Annotation

Function

Adapter protein which associates with tyrosine- phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors. {ECO:0000269PubMed:10026169, ECO:0000269PubMed:16835242, ECO:0000269PubMed:17803907, ECO:0000269PubMed:18835251, ECO:0000269PubMed:23358419, ECO:0000269PubMed:9430661}.

Subcellular Localization

Cytoplasm. Endoplasmic reticulum. Nucleus. Note=Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Import into the nucleus requires the interaction with SOCS7. Predominantly nuclear following genotoxic stresses, such as UV irradiation, hydroxyurea or mitomycin C treatments.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 142 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	142 [view]
Protein-Protein	141 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004860	protein kinase inhibitor activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008093	cytoskeletal adaptor activity
GO:0019887	protein kinase regulator activity
GO:0019904	protein domain specific binding
GO:0030159	receptor signaling complex scaffold activity
GO:0030971	receptor tyrosine kinase binding

Biological Process

GO:0006417	regulation of translation
GO:0006469	negative regulation of protein kinase activity
GO:0007015	actin filament organization
GO:0007172	signal complex assembly
GO:0007411	axon guidance
GO:0016477	cell migration
GO:0030032	lamellipodium assembly
GO:0030838	positive regulation of actin filament polymerization
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042102	positive regulation of T cell proliferation
GO:0042110	T cell activation
GO:0045087	innate immune response
GO:0045859	regulation of protein kinase activity
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050852	T cell receptor signaling pathway
GO:0051707	response to other organism
GO:0060548	negative regulation of cell death

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0012506	vesicle membrane