InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HMGCR

Summary

InnateDB Protein

IDBP-477842.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HMGCR

Protein Name

3-hydroxy-3-methylglutaryl-CoA reductase

Synonyms

LDLCQ3;

Species

Homo sapiens

Ensembl Protein

ENSP00000420871

InnateDB Gene

IDBG-28893 (HMGCR)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0050662	coenzyme binding

Biological Process

GO:0015936	coenzyme A metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR002202 Hydroxymethylglutaryl-CoA reductase, class I/II
IPR009023 Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain
IPR009029 Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain

PFAM

PF00368

PRINTS

PR00071

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite