InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ALG11

Summary

InnateDB Protein

IDBP-477901.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALG11

Protein Name

asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000430236

InnateDB Gene

IDBG-401899 (ALG11)

Protein Structure

UniProt Annotation

Function

Mannosyltransferase involved in the last steps of the synthesis of Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum. Catalyzes the addition of the 4th and 5th mannose residues to the dolichol- linked oligosaccharide chain. {ECO:0000269PubMed:20080937}.

Subcellular Localization

Endoplasmic reticulum {ECO:0000269PubMed:20080937}. Endoplasmic reticulum membrane {ECO:0000305PubMed:20080937}; Multi-pass membrane protein {ECO:0000305PubMed:20080937}.

Disease Associations

Congenital disorder of glycosylation 1P (CDG1P) [MIM:613661]: A multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N- glycoproteins during embryonic development, differentiation, and maintenance of cell functions. {ECO:0000269PubMed:20080937, ECO:0000269PubMed:22213132}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004377	GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity

Biological Process

GO:0006488	dolichol-linked oligosaccharide biosynthetic process
GO:0009058	biosynthetic process
GO:0018279	protein N-linked glycosylation via asparagine
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0097502	mannosylation