Homo sapiens Protein: BRCA1
Summary
InnateDB Protein IDBP-477993.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BRCA1
Protein Name breast cancer 1, early onset
Synonyms BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PPP1R53; PSCP; RNF53;
Species Homo sapiens
Ensembl Protein ENSP00000419481
InnateDB Gene IDBG-52172 (BRCA1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 625 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 625 [view]
Protein-Protein 603 [view]
Protein-DNA 15 [view]
Protein-RNA 0
DNA-DNA 7 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006281 DNA repair
GO:0016567 protein ubiquitination
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001357 BRCT domain
IPR011364 Breast cancer type 1 susceptibility protein (BRCA1)
PFAM PF00533
PF12738
PRINTS PR00493
PIRSF PIRSF001734
SMART SM00292
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q9UE29
UniProt Splice Variant
Entrez Gene 672
UniGene Hs.622171
RefSeq
HUGO HGNC:1100
OMIM 113705
CCDS
HPRD 00218
IMGT
EMBL AC135721 FJ940752 JX480461 JX480462 Y08757
GenPept ACR33809 AFU88803 AFU88804 CAA70003