InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DPEP1

Summary

InnateDB Protein

IDBP-47800.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DPEP1

Protein Name

dipeptidase 1 (renal)

Synonyms

MBD1; MDP; RDP;

Species

Homo sapiens

Ensembl Protein

ENSP00000261615

InnateDB Gene

IDBG-47798 (DPEP1)

Protein Structure

UniProt Annotation

Function

Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity.

Subcellular Localization

Apical cell membrane; Lipid-anchor, GPI- anchor. Cell projection, microvillus membrane; Lipid-anchor, GPI- anchor. Note=Brush border membrane.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008235	metalloexopeptidase activity
GO:0008237	metallopeptidase activity
GO:0008239	dipeptidyl-peptidase activity
GO:0008270	zinc ion binding
GO:0016805	dipeptidase activity
GO:0034235	GPI anchor binding
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0046872	metal ion binding
GO:0070573	metallodipeptidase activity
GO:0072341	modified amino acid binding

Biological Process

GO:0006508	proteolysis
GO:0006691	leukotriene metabolic process
GO:0006749	glutathione metabolic process
GO:0016999	antibiotic metabolic process
GO:0019369	arachidonic acid metabolic process
GO:0030336	negative regulation of cell migration
GO:0035690	cellular response to drug
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044281	small molecule metabolic process
GO:0050667	homocysteine metabolic process
GO:0071277	cellular response to calcium ion
GO:0071732	cellular response to nitric oxide
GO:0072340	cellular lactam catabolic process

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0016324	apical plasma membrane
GO:0031225	anchored component of membrane
GO:0031528	microvillus membrane
GO:0045177	apical part of cell
GO:0070062	extracellular vesicular exosome