InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ACSM1

Summary

InnateDB Protein

IDBP-478196.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACSM1

Protein Name

acyl-CoA synthetase medium-chain family member 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000428650

InnateDB Gene

IDBG-18511 (ACSM1)

Protein Structure

UniProt Annotation

Function

Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro). Functions as GTP-dependent lipoate- activating enzyme that generates the substrate for lipoyltransferase (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003996	acyl-CoA ligase activity
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0046872	metal ion binding
GO:0047760	butyrate-CoA ligase activity

Biological Process

GO:0006805	xenobiotic metabolic process
GO:0008152	metabolic process
GO:0015980	energy derivation by oxidation of organic compounds
GO:0018874	benzoate metabolic process
GO:0019395	fatty acid oxidation
GO:0019605	butyrate metabolic process
GO:0042632	cholesterol homeostasis
GO:0044281	small molecule metabolic process