InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TOB1

Summary

InnateDB Protein

IDBP-478234.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TOB1

Protein Name

transducer of ERBB2, 1

Synonyms

APRO6; PIG49; TOB; TROB; TROB1;

Species

Homo sapiens

Ensembl Protein

ENSP00000427695

InnateDB Gene

IDBG-59376 (TOB1)

Protein Structure

UniProt Annotation

Function

Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. {ECO:0000269PubMed:23236473, ECO:0000269PubMed:8632892}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Only a small fraction localizes to the cytoplasm except in late S-phase where more than half of proteins become cytoplasmic. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.

Experimentally validated
Total	39 [view]
Protein-Protein	37 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0005070	SH3/SH2 adaptor activity
GO:0005515	protein binding
GO:0030971	receptor tyrosine kinase binding
GO:0046332	SMAD binding

Biological Process

GO:0007184	SMAD protein import into nucleus
GO:0008285	negative regulation of cell proliferation
GO:0009967	positive regulation of signal transduction
GO:0017148	negative regulation of translation
GO:0030514	negative regulation of BMP signaling pathway
GO:0045668	negative regulation of osteoblast differentiation
GO:0060212	negative regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:1900153	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:2001141	regulation of RNA biosynthetic process