Version 5.4
Homo sapiens Protein: RAB11FIP1
Summary
InnateDB Protein IDBP-478339.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAB11FIP1
Protein Name RAB11 family interacting protein 1 (class I)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000430680
InnateDB Gene IDBG-17106 (RAB11FIP1)
Protein Structure
UniProt Annotation
Function A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. {ECO:0000269PubMed:11786538, ECO:0000269PubMed:15181150, ECO:0000269PubMed:15355514, ECO:0000269PubMed:16920206}.
Subcellular Localization Recycling endosome {ECO:0000269PubMed:11786538, ECO:0000269PubMed:15181150, ECO:0000269PubMed:15280022, ECO:0000269PubMed:15355514, ECO:0000269PubMed:16920206}. Note=Rab11A rather than Rab4A mediates localization in the endocytic recycling compartment (ERC).Isoform 2: Cytoplasmic vesicle, phagosome membrane. Note=Membrane-bound (isoform 2). Colocalizes with Rab11A at phagosomes (isoform 2).
Disease Associations
Tissue Specificity Isoform 2 is expressed in brain, heart, testis, lung, spleen, ovary and small intestine. {ECO:0000269PubMed:11786538}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0015031 protein transport
Cellular Component
GO:0005737 cytoplasm
GO:0030670 phagocytic vesicle membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0055037 recycling endosome
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6WKZ4
PhosphoSite PhosphoSite-Q6WKZ4
TrEMBL
UniProt Splice Variant
Entrez Gene 80223
UniGene Hs.722480
RefSeq
HUGO HGNC:30265
OMIM 608737
CCDS
HPRD 09787
IMGT
EMBL AC130304 AF368294 AK026275 AK122583 AK291781 AY280966 AY280968 AY280970 BC077720 DQ236342
GenPept AAH77720 AAM09571 AAQ18784 AAQ18786 AAQ18788 ABB43161 BAB15424 BAC56924 BAF84470

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca