InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: COX17

Summary

InnateDB Protein

IDBP-478343.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COX17

Protein Name

COX17 cytochrome c oxidase assembly homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000417805

InnateDB Gene

IDBG-51411 (COX17)

Protein Structure

UniProt Annotation

Function

Copper chaperone for cytochrome c oxidase (COX). Binds two copper ions and deliver them to the Cu(A) site of COX (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion intermembrane space {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:10982038}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005507	copper ion binding
GO:0016531	copper chaperone activity

Biological Process

GO:0006091	generation of precursor metabolites and energy
GO:0006825	copper ion transport

Cellular Component

GO:0005737	cytoplasm
GO:0005758	mitochondrial intermembrane space

Protein Structure and Domains

PDB ID

InterPro

IPR007745 Cytochrome c oxidase copper chaperone
IPR009069 Cysteine alpha-hairpin motif superfamily

PFAM

PF05051

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q14061

PhosphoSite

PhosphoSite-Q14061

TrEMBL

UniProt Splice Variant

Entrez Gene

10063

UniGene

RefSeq

HUGO

HGNC:2264

OMIM

604813

CCDS

CCDS2993

HPRD

05314

IMGT

EMBL

AF269243 AF269244 AK312143 BC010933 BC105280 BC108317 CH471052 L77701

GenPept

AAA98114 AAF82569 AAH10933 AAI05281 AAI08318 BAG35079 EAW79545 EAW79547 EAW79548 EAW79550 EAW79551