InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TCEB1

Summary

InnateDB Protein

IDBP-478404.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TCEB1

Protein Name

transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)

Synonyms

eloC; SIII;

Species

Homo sapiens

Ensembl Protein

ENSP00000428334

InnateDB Gene

IDBG-25766 (TCEB1)

Protein Structure

UniProt Annotation

Function

SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). {ECO:0000269PubMed:15590694}.The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC- box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes. {ECO:0000269PubMed:15590694}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Overexpressed in prostate cancer cell line PC- 3 and breast cancer cell line SK-BR-3. {ECO:0000269PubMed:12004003}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 191 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	191 [view]
Protein-Protein	191 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0010467	gene expression
GO:0016032	viral process
GO:0045087	innate immune response (InnateDB)
GO:0050434	positive regulation of viral transcription
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0071456	cellular response to hypoxia