InnateDB Protein
|
IDBP-478730.4
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
MYD88
|
Protein Name
|
myeloid differentiation primary response gene (88)
|
Synonyms
|
MYD88D;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000417848
|
InnateDB Gene
|
IDBG-25713 (MYD88)
|
Protein Structure
|
|
Function |
Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine. {ECO:0000269PubMed:15361868, ECO:0000269PubMed:18292575, ECO:0000269PubMed:19506249, ECO:0000269PubMed:9013863}.
|
Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:15361868, ECO:0000269PubMed:15492225}.
|
Disease Associations |
MYD88 deficiency (MYD88D) [MIM:612260]: Patients suffer from autosomal recessive, life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease, and die between 1 and 11 months of age. Surviving patients are otherwise healthy, with normal resistance to other microbes, and their clinical status improved with age. {ECO:0000269PubMed:18669862}. Note=The disease is caused by mutations affecting the gene represented in this entry.
|
Tissue Specificity |
Ubiquitous. {ECO:0000269PubMed:8957090}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 129 experimentally validated interaction(s) in this database.
They are also associated with 59 interaction(s) predicted by orthology.
Experimentally validated |
Total |
129
[view]
|
Protein-Protein |
120
[view]
|
Protein-DNA |
2
[view]
|
Protein-RNA |
0
|
DNA-DNA |
7
[view]
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
59 [view]
|
|
|
Molecular Function |
|
Biological Process |
GO:0002224
|
toll-like receptor signaling pathway
|
GO:0002755
|
MyD88-dependent toll-like receptor signaling pathway
|
GO:0006954
|
inflammatory response
|
GO:0007165
|
signal transduction
|
GO:0007166
|
cell surface receptor signaling pathway
|
GO:0032481
|
positive regulation of type I interferon production
|
GO:0032740
|
positive regulation of interleukin-17 production
|
GO:0032747
|
positive regulation of interleukin-23 production
|
GO:0032755
|
positive regulation of interleukin-6 production
|
GO:0034134
|
toll-like receptor 2 signaling pathway
|
GO:0034142
|
toll-like receptor 4 signaling pathway
|
GO:0034146
|
toll-like receptor 5 signaling pathway
|
GO:0034162
|
toll-like receptor 9 signaling pathway
|
GO:0034166
|
toll-like receptor 10 signaling pathway
|
GO:0038123
|
toll-like receptor TLR1:TLR2 signaling pathway
|
GO:0038124
|
toll-like receptor TLR6:TLR2 signaling pathway
|
GO:0043066
|
negative regulation of apoptotic process
|
GO:0043123
|
positive regulation of I-kappaB kinase/NF-kappaB signaling
|
GO:0045087
|
innate immune response (InnateDB)
|
GO:0048011
|
neurotrophin TRK receptor signaling pathway
|
GO:0050727
|
regulation of inflammatory response
|
GO:0050830
|
defense response to Gram-positive bacterium
|
GO:0070555
|
response to interleukin-1
|
GO:0070935
|
3'-UTR-mediated mRNA stabilization
|
GO:0071260
|
cellular response to mechanical stimulus
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR000488
Death domain
IPR011029
Death-like domain
|
PFAM |
PF00531
|
PRINTS |
|
PIRSF |
|
SMART |
SM00005
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q99836
|
PhosphoSite |
PhosphoSite-Q99836
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
4615
|
UniGene |
Hs.82116
|
RefSeq |
NP_001166037
|
HUGO |
HGNC:7562
|
OMIM |
602170
|
CCDS |
CCDS54568
|
HPRD |
03703
|
IMGT |
|
EMBL |
AB446470
AK296570
AK296716
AK298650
AK298666
AP006309
BC013589
BI524129
BT007376
CH471055
U70451
U84408
|
GenPept |
AAB49967
AAC50954
AAH13589
AAP36040
BAG55247
BAG59190
BAG59306
BAG60822
BAG60834
EAW64521
|
|
|